Erratum: Structural Mechanism for Regulation of Bcl-2 protein Noxa by phosphorylation
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Structural Mechanism for Regulation of Bcl-2 protein Noxa by phosphorylation
We showed previously that phosphorylation of Noxa, a 54-residue Bcl-2 protein, at serine 13 (Ser13) inhibited its ability to promote apoptosis through interactions with canonical binding partner, Mcl-1. Using EPR spectroscopy, molecular dynamics (MD) simulations and binding assays, we offer evidence that a structural alteration caused by phosphorylation partially masks Noxa's BH3 domain, inhibi...
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